基本信息
徐广宇，1999年3月获湖南大学应用化学专业硕士学位，硕士毕业后分配至湖南省轻工研究院从事科研工作， 2001年9月考入中国科学院上海药物研究所攻读博士学位，导师为谢毓元院士，2004年6月获理学博士学位。2004年9月博士毕业分配至伟德始于英国1946工作，现从事抗骨质疏松药物、抗肿瘤药物的合成及药物工艺研究工作。主持国家自然科学基金(20602010) 、湖南省自然科学基金项目 (06JJ50024) 和湖南省教育厅青年项目(10B061)各一项，2007年获得伟德始于英国1946青年优秀人才培养基金资助。参与国家科技部九五重点攻关项目子课题(96-A12-05-10)和国家863项目(2007AA06Z403)各一项。承担企业横向项目多项。获得专利授权3项， 在Bioorg. Med. Chem. Lett.，Steroids，Tetrahedron Letters，Synthesis等SCI期刊上发表论文十多篇。湖南省新药审评专家。
联系信息
E-mail: gyxu@hunnu.edu.cn
代表性研究论文
1.Guangyu Xu, Chunhao Yang, et al. Catechol-bisphosphonate conjugates: new potential chelating agents for metal intoxication therapy.Chinese Chem. Lett.2004, 15(12), 1403-1406.
2.Guangyu Xu, Yuyuan Xie, et al. A facile and direct synthesis of alendroante from pyrrolidone. Org. Prep. & Proc. Int.2004, 36(2), 185-7.
3.Guangyu Xu, Chunhao Yang, et al. Synthesis of new potential chelating agents catechol-bisphosphonate conjugates for metal intoxication therapy.Heteroatom Chem. 2004, 15(3), 251-257.
4.Huasheng Ding, Guangyu Xu, et al. Catechol–bisphosphonate conjugates: new types of chelators for metal intoxication therapy. Heteroatom Chem. 2004, 15(7), 549-555.
5.Chunhao Yang, Guangyu Xu, et al. Benzothiophenes containing a piperazine side chain as selective ligands for the estrogen receptor α and their bioactivities in vivo.Bioorg. Med. Chem. Lett. 2005, 15(5), 1505-1507.
6.Bo Liu, Guangyu Xu, et al. A novel and facile method to synthesize (R) and (S)-2-methylpiperazine.Synthetic Communications 2004 34(22), 4111-4118.
7.Guangyu Xu, Yi Zhou, et al. A convenient synthesis of antibacterial Linezolid from ascorbic acid.Chinese Chem. Lett. 2006, 17(3) 302-304
8.Guangyu Xu, Yi Zhou, Gaolei Zuo, Yongjun Jiang. An improved procedure for synthesis of a-asarone.Org. Prep. & Proc. Int.. 2007, 39 (5), 514-517.
9. Guangyu Xu, Yi Zhou, Chunhao Yang, Yuyuan Xie. An effective synthesis of linezolid and eperezolid using (S)-glyceraldehyde acetonide as chiral building block.Heteroatom Chemistry 2008, 19 (3), 316-319.
10.Guangyu Xu, Chang Liu, Wei Zhang, Gaolei Zuo. A practical synthesis of α-asarone via iodine-catalyzed isomerization of α/β-asarone.Org. Prep. & Proc. Int.. 2009, 41(2), 152-155.
11.徐广宇，周伊，左高磊，蒋勇军. 1-氨基-7-甲氧基-β-咔啉及其1-烷氧羰基氨基衍生物的合成和初步抗肿瘤活性研究.有机化学,2009, 29(10),1593-1597.
12.‘Long-Range’ Pummerer-Type Cyclization: A Simple and Facile Synthesis of 5-Vinyl-1,3-oxazoles Guangsyu Xu, Kaixiong Chen, Hongwei Zhou.Synthesis,2009, (21) 3565-3570.
13. Guangyu Xu, Gaolei Zuo, Shihua Zhong, Wei Zhang.Synthesis and Hydroxyapatite Binding Activity of Bisphosphonate-Statin Conjugates.Lett. Org. Chem. 2009, 6(5), 419-423.
14. Kaixiong Chen, Chang Liu, Guangyu Xu.*A practical 1-dehydroge- nation of 4-3-keto- steroids with DDQ in the presence of TBDMSCl at room temperature. Steroids,2010, 75, 513–16
15. Guangyu Xu, Kaixiong Chen, Hongwei Zhou.Sulfur-assisted propargyl–allenyl isomerizations and intramolecular cyclization for the synthesis of tricyclic thiophene derivatives.Tetrahedron Letters, 2010, 51(48), 6240-6242
