尹鹏

*教育经历*

2007年8月 - 2012年4月 新加坡南洋理工大学 博士研究生 导师: Prof Loh Teck Peng

2003年9月 - 2006年7月 中国协和医科大学 硕士研究生 导师: 王荣先 教授

1999年9月 - 2003年7月 吉林大学 本科

*工作经历*

2018年12月 - 至今 伟德始于英国1946 教授

2012年8月 - 2018年12月  伟德始于英国1946 讲师

2012年4月 - 2012年8月 康宝莱蕾硕（湖南）天然产物有限公司

2006年7月 - 2007年7月 上海药明康德新药开发有限公司

*研究方向*

以化学为核心，在化学、生物、医学、环境等交叉领域，围绕荧光探针与传感、成像研究开展工作，具体研究方向有：

1. 生物体系中氧化还原调控的分子机制探索、活性硫物质及相关疾病标志物的同时传感与调控；

2. 小分子探针及生物活性分子、酶、金属的荧光传感；

3. 体外诊断试剂盒、生物染料及精细化工品的研究开发。

*主持课题*

11, 同时区分检测同型半胱氨酸和β-淀粉样蛋白低聚物荧光探针的构建及其在阿尔茨海默病中的应用（NO. 22277026），国家自然科学基金面上项目，2023年-2026年；

10, 选择性检测同型半胱氨酸荧光探针的构建及其在阿尔茨海默病中的应用（NO. 22A0037），湖南省教育厅重点项目，2023年-2025年；

9, 阿尔茨海默病中同型半胱氨酸的动态荧光成像研究（NO. 2023JJ30391)，湖南省自然科学基金面上项目，2023年-2025年；

8, 生物新材料的研究开发（NO. 2021GK5088），湖南省科技厅，2022年-2023年；

7, 生物功能材料及IVD试剂的研究开发，2021年-2028年；

6, 同时区分Cys, Hcy和GSH的近红外荧光探针的构建及荧光定量研究（NO. 21877035），国家自然科学基金面上项目，2019年-2022年；

5, 血清中小分子生物硫醇的荧光定量研究，湖南省教育厅优秀青年项目，2018年-2020年；

4, 新型化学发光试剂及生物新材料的研究开发，2017年-2024年；

3, 碱性磷酸酶检测体系的底物的开发，2016年-2019年；

2, 检测β-内酰胺酶的荧光小分子探针的设计、合成及其在检测结核杆菌中的应用（NO. 21405043），国家自然科学基金青年基金，2015年-2017年；

1, 新型阻燃剂的合成研究，2014年-2016年；

*学术论文*

1, Guoxing Yin,^# Tingting Niu,^# Ting Yu,^# Yabing Gan, Xinyu Sun, Peng Yin*, Haimin Chen*, Youyu Zhang, Haitao Li* and Shouzhuo Yao. Simultaneous Visualization of Endogenous Homocysteine, Cysteine, Glutathione, and their Transformation through Different Fluorescence Channels. Angew. Chem., Int. Ed., 2019, 58, 4557-4561.

2, Guoxing Yin, Tingting Niu, Yabing Gan, Ting Yu, Peng Yin*, Haimin Chen*, Youyu Zhang, Haitao Li* and Shouzhuo Yao, A Multi-signal Fluorescent Probe with Multiple Binding Sites for Simultaneous Sensing of Cysteine, Homocysteine and Glutathione.  Angew. Chem., Int. Ed., 2018, 57, 4991-4994.

3, Guoxing Yin, Yabing Gan, Huimin Jiang, Ting Yu, Meiling Liu, Youyu Zhang, Haitao Li, Peng Yin*, and Shouzhuo Yao. Direct Quantification and Visualization of Homocysteine, Cysteine, and Glutathione in Alzheimer’s and Parkinson’s Disease Model Tissues. Anal. Chem., 2021, 93, 9878-9886.

4, Guoxing Yin, Yabing Gan, Huimin Jiang, Ting Yu, Meiling Liu, Youyu Zhang, Haitao Li, Peng Yin*, and Shouzhuo Yao. General Strategy for Specific Fluorescence Imaging of Homocysteine in Living Cells and in Vivo. Anal. Chem., 2023, 95, 8932-8938.

5, Yabing Gan, Guoxing Yin, Zhaomin Xu, Huyang Zhou, Ting Yu, Haitao Li, Peng Yin*. A dual-functional fluorescent probe for simultaneous visualization and quantification of Au and Pd species in environmental and biological systems. Chem. Eng. J., 2023, 451, 138437.

6, Peng Yin  and Teck-Peng Loh *. Intermolecular Hydroamination between Nonactivated Alkenes and Aniline Catalyzed by Lanthanide Salts in Ionic Solvents. Org. Lett., 2009, 17, 3791-3793.  

7, Peng Yin,  Mun Yee Wong, Jieying Tham,and Teck-Peng Loh*.  Palladium-catalyzed amination of allylic carbonates with ammonia: access to primary amines. Org. Chem. Front., 2014, 1, 1266-1269.

8, Ting Yu, Guoxing Yin, Peng Yin*, Ying Zeng, Haitao Li*, Youyu Zhang and Shouzhuo Yao. A novel long-wavelength fluorescent probe for discrimination of different palladium species based on Pd-catalyzed reactions. RSC Adv., 2017, 7, 24822–24827.

9,  Guoxing Yin, Ting Yu, Tingting Niu, Peng Yin*, Haimin Chen, Youyu Zhang, Haitao Li* and Shouzhuo Yao. A novel fluorescence turn-on probe for the selective detection of thiophenols by caged benzooxazolidinoindocyanine. RSC Adv., 2017, 7 46148-46154.  

10, Hai Xu, Biao Gu, Yaqian Li, Zhen Huang, Wei Su, Xiaoli Duan, Peng Yin*, Haitao Li* and Shouzhuo Yao. A highly selective, colorimetric and ratiometric fluorescent probe for NH₂NH₂ and its bioimaging. Talanta, 2018, 180, 199-205.

11, Ting Yu, Guoxing Yin,Tingting Niu, Peng Yin*, Haitao Li*, Youyu Zhang, Haimin Chen*, Ying Zeng and Shouzhuo Yao. A novel colorimetric and fluorescent probe for simultaneous detection of SO₃^2-/HSO₃^- and HSO₄^- by different emission channels and its bioimaging in living cells. Talanta, 2018, 176, 1–7.

12, Tingting Niu,^# Ting Yu,^# Guoxing Yin, Haimin Chen*, Peng Yin* and Haitao Li. A novel colorimetric and ratiometric fluorescent probe for sensing SO₂ derivatives and their bio-imaging in living cells. Analyst, 2019, 144, 1546-1554.

13, Guoxing Yin, Jingfeng Yao, Sai Hong, Yinuo Zhang, Zhaohua Xiao, Ting Yu*, Haitao Li and Peng Yin*. A Dual-responsive Colorimetric Probe for Detection of Cu²⁺ and Ni²⁺ Species in Real Water Samples and Human Serum. Analyst, 2019, 144, 6962-6967.

14, Guoxing Yin, Yabing Gan, Ting Yu, Tingting Niu, Peng Yin*, Haimin Chen, Youyu Zhang, Haitao Li and Shouzhuo Yao. A dual-emission and mitochondria-targeted fluorescent probe for rapid detection of SO₂ derivatives and its imaging in living cells. Talanta, 2019, 191, 428-434. (IF=6.057)

15, Tingting Niu,# Guoxing Yin,# Ting Yu, Yabing Gan, Chenye Zhang, Juanjuan Chen, Wei Wu, Haimin Chen,* Haitao Li, Peng Yin*. A novel fluorescent probe for detection of Glutathione dynamics during ROS-induced redox imbalance. Anal. Chim. Acta, 2020, 1115, 52-60.

16, Yabing Gan, Guoxing Yin, Ting Yu, Youyu Zhang, Haitao Li and Peng Yin*. A Novel Fluorescent Probe for Selective Imaging of Cellular Cysteine with Large Stokes Shift and High Quantum Yield. Talanta, 2020, 210, 120612. 

17, Guoxing Yin, Ting Yu*, Yabing Gan, Li Zhou*, Meiling Liu, Youyu Zhang, Haitao Li, Peng Yin* and Shouzhuo Yao. A novel fluorescent probe with dual-sites for simultaneously monitoring metabolisms of cysteine in living cells and zebrafishes. Spectrochim. Acta, Part A, 2020, 241, 118602.

18, Yabing Gan, Guoxing Yin, Xiaming Zhang, Li Zhou*, Yibao Zhang*, Haitao Li, Peng Yin*. Turn-on fluorescent probe for sensing exogenous and endogenous hypochlorous acid in living cells, zebrafishes and mice. Talanta 2021, 225, 122030.

19, Jingfeng Yao, Guoxing Yin, Ting Yu, Haitao Li, Peng Yin*. Simultaneous sensing of cysteine/homocysteine and glutathione with a fluorescent probe based on a single atom replacement strategy. Anal. Methods, 2021, 13, 1358-1363.

20, Jie Chen, Yabing Gan, Sai Hong, Guoxing Yin, Li Zhou*, Changze Wang, Yuchuan Fu, Haitao Li, Peng Yin*. A novel red emission fluorescent probe for monitoring carbon monoxide in living cells and zebrafish. Anal. Methods, 2021, 13, 2871-2877

21, Gaoqing Fu,# Guoxing Yin,# Tingting Niu, Wei Wu, Hui Han, Haimin Chen*, Peng Yin*. A novel ratiometric fluorescent probe for the detection of mitochondrial pH dynamics during cell damage. Analyst, 2021, 146, 620-627.

22, Huimin Jiang, Guoxing Yin, Yabing Gan, Ting Yu, Youyu Zhang, Haitao Li, Peng Yin*. A multisite-binding fluorescent probe for simultaneous monitoring of mitochondrial homocysteine, cysteine and glutathione in live cells and zebrafish. Chin. Chem. Lett., 2022, 33, 1609-1621.

23, Yabing Gan, Guoxing Yin, Jianhua Wang*, Peng Yin*. A novel AIE fluorescent probe for the monitor of aluminum ion in living cells and zebrafish. Analyst, 2022, 147, 2828-2833.

*授权专利*

1, 一种新型检测苯硫酚荧光分子探针的制备方法和应用。

2, 一种线粒体靶向pH比率型荧光探针的制备方法和应用。

3, 多信号荧光探针的合成及其同时区分检测Hcy、Cys和GSH的应用。

4, 一种比色法检测水中Cu和Ni探针的合成与应用。

5, 一种同时区分羟基自由基和过氧化氢的双功能荧光探针的合成与应用。

6, 同时检测羟基自由基和粘度的双功能荧光探针的合成与应用。

7, 多信号荧光探针的合成及其在检测Cys、GSH和Hcy中的应用。

8, 多信号荧光探针的合成及其同时区分Cys、SO₂、GSH和Hcy的应用

9, 一种同时区分金离子与钯物种的荧光探针的合成及应用

10, 多信号荧光探针的合成及其同时区分Hcy、Cys、SO₂和GSH的应用

*学术兼职*

中国生物物理学会生物微量元素分会委员

OPCW后备人才

Chinese Chemical Letters 青年编委

*联系方式*

yinpeng@hunnu.edu.cn